Bio Knowledge is a system for conducting gene or protein mechanism searches. It makes use of a database that contains a centralized collection of protein, gene, genome disease, and organ annotations. This system can be used as a dictionary, to view annotation information, and to conduct analyses of GO terms, diseases, and compounds for groups of genes obtained from microarray experiments.
In particular, in analyses targeting gene groups, the functionality of gene groups or trends seen with certain diseases or compounds can be objectively identified. Since almost all compounds include structural information, it is possible to analyze data from their Chem Knowledge structures.
Another preferred method of analysis is to use literature co-occurrence data. This method utilizes literature search results compiled during the use of various dictionary functions.

Features of the Bio Knowledge Functions

As shown below, Bio Knowledge allows for the development of annotations for genes, proteins, diseases, and compounds from various angles.

Gene Information

• Search for gene synonyms by using ambiguous expressions and retrieve the latest information on gene registrations and their functions.
• Search for genes using accession ID, GO, or GeneID
• Analyze ontology functions (GO), disease, and compounds using gene lists.
• Use genes to survey proteins, domains, and 3D structural information.
• Search for ortholog genes
• Survey genes linked to PDB 3D structures or Bioassay
• Search for proteins based on their molecular mass
• Search for proteins that are drug targets (data source: DrugBank)

Disease Information

• Use disease terms categorized as ICD10, MeSH, or others as keywords to search for information about literature, genes, organs, etc. to survey their relationships.

Compound Information

• Use keywords to find various compounds
• Please refer to "Chem Knowledge" for extended information based on chemical structures